Frederic Chedin

Frederic Chedin

Position Title
Professor

Unit
Molecular & Cellular Biology


Bio

Dr. Chedin's main research goal is to provide an understanding of the molecular mechanisms that govern the deposition of cytosine DNA methylation patterns in human cells. Two active and complementary areas of investigations center around: 1) the function of human DNA methyltransferases and 2) the mechanisms by which promoter regions escape DNA methylation and epigenetic silencing. The studies have direct relevance for cancer research since aberrant DNA methyltransferase activity and inappropriate marking and silencing of tumor-suppressor genes are two hallmarks of human cancers.