David J. Segal

David Segal

Position Title
Professor

Unit
Biochemistry & Molecular Medicine


Bio

Specific research foci in the Segal Lab revolve around engineering custom DNA-binding proteins for the following applications:

  • Gene therapy: Molecular Therapy for Angelman and Prader-Willi Syndromes
  • Zinc finger, TALE, and CRISPR/Cas programmable DNA binding systems: targeted nucleases, epigenetic modifiers, transposases, transcription factors.
  • Genetic variation and diseases: Genome Engineering to study SNP and enhancer functions

Trainees: