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A c-Myc and N-Myc double knockout P6 cerebellum, stained in green for the tumor suppressor p27KIP1

A c-Myc and N-Myc double knockout P6 cerebellum, stained in green for the tumor suppressor p27KIP1, exhibits dramatically elevated KIP1. This data from the Knoepfler Laboratory suggest that excess Myc may cause the pediatric brain tumor medulloblastoma in part through suppressing KIP1 leading to cancer stem cell formation.

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